Clinical data analysis and appraisal play a crucial role in the evaluation of medical devices for compliance with the Medical Device Regulation (MDR). It involves a systematic and rigorous examination of the gathered clinical data to assess the safety, performance, and effectiveness of the device. Various data sources, including preclinical and clinical studies, post-market surveillance, and standard of care evidence. The process ensures that the medical device meets the required standards and demonstrates its clinical benefits and risk management. A comprehensive and well-documented analysis is essential to meet MDR requirements.